indoleamine 2,3-dioxygenase and immunological tolerance during pregnancy

نویسندگان

amir hassan zarnani

department of immunology, tarbiat modarres university pouneh dokouhaki

department of immunology, monoclonal antibody research center, avesina research institute, tehran, iran and mahmood jeddi-tehrani

department of immunology, monoclonal antibody research center, avesina research institute, tehran, iran and

چکیده

indoleamine 2,3-dioxygenase (ido), an enzyme involved in the catabolism of tryptophan, is expressed by a variety of cells and tissues such as macrophages, dendritic cells, cells of the endocrine system and by the placenta. ifn- γ is the main inducer of this enzyme. ido acts as an important defense mechanism of innate immunity against pathogens. it also has tumor suppressive activity and prolongs the survival of allograft. one of the interesting functions of ido is prevention of the allogenic fetus rejection during pregnancy by inhibiting alloreactive t cells. it was shown that inhibition of ido activity by ido inhibitor, 1-methyl tryptophan, during mouse pregnancy causes fetal rejection. the main mechanism by which ido protects fetus is through reducing the tryptophan level and suppressing the t cell activity in the feto-maternal interface. in this review the biological functions of ido with emphasis on its role in allogeneic fetus protection have been discussed.

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منابع مشابه

Indoleamine 2,3-Dioxygenase and Immunological Tolerance during Pregnancy

Indoleamine 2,3-dioxygenase (IDO), an enzyme involved in the catabolism of tryptophan, is expressed by a variety of cells and tissues such as macrophages, dendritic cells, cells of the endocrine system and by the placenta. IFN- γ is the main inducer of this enzyme. IDO acts as an important defense mechanism of innate immunity against pathogens. It also has tumor suppressive activity and prolong...

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Indoleamine 2,3-Dioxygenase and Immunological Tolerance during Pregnancy

Indoleamine 2,3-dioxygenase (IDO), an enzyme involved in the catabolism of tryptophan, is expressed by a variety of cells and tissues such as macrophages, dendritic cells, cells of the endocrine system and by the placenta. IFN-γ is the main inducer of this enzyme. IDO acts as an important defense mechanism of innate immunity against pathogens. It also has tumor suppressive activity and prolongs...

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Indoleamine 2,3-dioxygenase: From tolerance during pregnancy to cancer

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Indoleamine 2,3-dioxygenase (ido) and Immune Tolerance

The IDO facilitates immune tolerance and is one of the main actors involved in the inhibition of cell proliferation, including activated T cells. IDO induces production of reactive oxygen species (ROS) and nitric oxide (NO) radicals. Several pathways involved in the regulation of immune response are regulated by redox mechanisms. Reactive oxygen and nitrogen species (ROSRNS) and other redox act...

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Indoleamine 2,3-dioxygenase and tumor-induced tolerance.

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Indoleamine 2,3-Dioxygenase and Tolerance: Where Are We Now?

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عنوان ژورنال:
iranian journal of immunology

جلد ۱، شماره ۳، صفحات ۱۴۳-۱۵۳

کلمات کلیدی
[ ' i m m u n o l o g y ' , ' i n d o l e a m i n e 2 ' , 3 , ' d i o x y g e n a s e ' , ' p r e g n a n c y ' , ' t o l e r a n c e ' ]

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